e-ISSN 1694-2078
p-ISSN 1694-2086

Arch Med Biomed Res. 2015;2:?-. doi:10.4314/ambr.v2i4.4

KE Imafidon1, S Wuruyai1, S Odudu1, S Ighodalo1, SO Atewe1, IJ Akuneatiwu1, BI Egede1

Author Affiliations

1Biochemistry Department, Faculty of Life Sciences, University of Benin, Edo State, Nigeria

correspondence to
KE Imafidon; katevbu@gmail.com

Received: August 25, 2015
Revised: November 10, 2015
Accepted: November 11, 2015


This work was done as a part of safety assessment to determine the effects of Tartrazine E102 on some haematological indices, glucose levels and blood lipid profile in rats. An animal model was used as a basis for interpreting the situation in humans. Consequently, 40 albino rats were divided into 5 groups of 8 rats each. All the animals were fed rats’ mash and water and administered 0, 10, 20, 40 and 80mg/kg body weight of Tartrazine E102 respectively. Weekly measurements of body weight were recorded. Results obtained showed a significant reduction in body weight gain and blood glucose levels compared with the control. A non-dose dependent effect was observed on total cholesterol, LDL cholesterol, total white blood cells and monocytes. A slight but significant increase was observed in haematocrit at the highest dose levels. Conclusively, Tartrazine E102 exhibited a hypoglycemic effect in rats, no negative effect was observed on lipid profile.

KEY WORDS: Tartrazine E102; glucose; haematological; cholesterol; triacylglycerol


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