e-ISSN 1694-2078
p-ISSN 1694-2086

Arch Med Biomed Res. 2014;1:139-146. doi:10.4314/ambr.v1i4.3

Banibrata Das1, Juthika Kundu2, Sitesh Chandra Bachar1, Joydeb Kumar Kundu2

Author Affiliations

1Department of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
2College of Pharmacy, Keimyung University, Daegu 704-701, South Korea

correspondence to
Joydeb Kumar Kundu; kundujk@yahoo.com

Received: July 07, 2014
Revised: October 10, 2014
Accepted: October 11, 2014


The effects of hexane, ethylacetate and methanol extracts of whole plant parts of Ludwigia hyssopifolia Linn on carrageenan-induced rat paw edema, acetic acid-induced writhing, and diuresis in mice were studied. The hexane extract (LH) and ethylacetate extract (LE) showed maximal inhibition of carrageenan-induced paw edema by 33.96% and 27.39% after 2 h and 3 h of study, respectively, while the methanolic extract (LM) showed no remarkable effects. The study of anti-nociceptive activity of the extracts showed that all three fractions exhibited significant inhibition of writhing reflex in an order of LH > LE > LM. In comparison to furosemide, good diuretic activity was exhibited by all three extracts. The onset of diuretic action of LE and LM was rapid, while that of LH was relatively slow. Results of this preliminary pharmacological screening indicate that the plant Ludwigia hyssopifolia Linn holds the promise of being utilized in developing herbal medicines.

KEY WORDS: Ludwigia hyssopifolia Linn; Anti-inflammatory activity; Carrageenan; Diuretic activity


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