e-ISSN 1694-2078
p-ISSN 1694-2086

Arch Med Biomed Res. 2014;1:129-138. doi:10.4314/ambr.v1i4.2

Okikiola Olajide1, Maryam Aminu1, Abdullahi J Randawa2, Daniel S Adejo2

Author Affiliations

1Department of Microbiology, Faculty of Science, Ahmadu Bello University, Zaria, Kaduna, Nigeria
2Department of Obstetrics and Gynecology, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna, Nigeria

correspondence to
Maryam Aminu; maryamaminu@yahoo.com

Received: July 04, 2014
Revised: September 02, 2014
Accepted: September 05, 2014


Rubella is a contagious viral infection, which in pregnant women leads to infection of a developing fetus causing fetal death or Congenital Rubella Syndrome. A cross-sectional study involving 180 women was carried out between June and August 2012 to determine the seroprevalence of IgM antibody to rubella in their serum using ELISA. The women comprised 160 pregnant women attending the ante-natal clinic of Ahmadu Bello University Teaching Hospital, Zaria and 20 non-pregnant women of childbearing age studying at Ahmadu Bello University, Zaria. Prior to sample collection, structured questionnaires were administered to gather relevant medical information, obstetrical and socio-demographic characteristics from the women. IgM antibody was detected in 62 (38.8%) of the pregnant women and 8 (40%) of the non-pregnant women. The majority (33: 53.2%) of the pregnant women who were positive were in their second trimester while 11 (17.7%) were in their first trimester. Infection with Rubella virus was not significantly associated with age, clinical symptoms and the possible risk factors studied (p>0.05). The level of awareness and knowledge of rubella and its transmission was extremely low for both population and uneducated pregnant women had the highest prevalence (54.5%: 6/11). The study showed seroprevalence higher than any previous reports in Nigeria with almost equal rate amongst the two populations. The high prevalence suggests that an outbreak might have occurred during the time of the study and emphasizes the need for the initiation of a national rubella vaccination program in Nigeria.

KEY WORDS: Seroprevalence; IgM antibody; Rubella; Pregnant women; Zaria; Nigeria


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